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Camostat mesylate

Name: Camostat mesylate
Brand: TargetMol
SKU: T2391
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2391Cas No. 59721-29-8

Alias FOY-S980, FOY305, Camostat mesilate

Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.

Camostat mesylate

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Purity: 99.85%

Catalog No. T2391Alias FOY-S980, FOY305, Camostat mesilateCas No. 59721-29-8

Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$43	In Stock	In Stock
25 mg	$66	In Stock	In Stock
50 mg	$89	In Stock	In Stock
100 mg	$125	In Stock	In Stock
200 mg	$185	In Stock	In Stock
500 mg	$313	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.85%

Color:White

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.
Targets&IC50	ENaC:50 nM
In vitro	Camostat mesilate, at a concentration of 1 mg/g, is effective in preventing pancreatic atrophy and improving exocrine function in rats with DBTC-induced chronic pancreatitis. This compound also inhibits chronic inflammation and fibrosis in the pancreas caused by DBTC. It suppresses the development of pancreatic fibrosis and PSC activation, as well as monocyte infiltration and the expression of MCP-1 in serum and pancreatic tissues. When administered at a dose of 100 mg/kg, Camostat mesilate significantly increases body and pancreatic wet weight, and effectively reduces inflammatory changes and fibrosis in the pancreas by inhibiting gene expression of PAP, p8, and cytokines in chronic pancreatitis. In rats treated with pig serum, Camostat mesilate (1-2 mg/g in diet) notably decreases the levels of hepatic plasmin and TGF-β and inhibits HSC activation and liver fibrosis, without noticeable systemic or local side effects. Additionally, at a dose of 100 μg/kg intratracheally, Camostat prolongs the attenuation of ENaC activity in guinea pig tracheas.
In vivo	At a concentration of 2 mM, Camostat mesilate inhibits the production of MCP-1 and TNF-α in activated rat monocytes and the proliferation of rat pancreatic stellate cells (PSCs) along with MCP-1 production. In the presence of 20 mM Camostat mesilate, there is a notable reduction in blood glucose levels when combined with insulin and administered via the large intestine, effectively decreasing insulin degradation in the rat's small intestine and its homogenate. A 30 μM concentration of Camostat prolongs the decay of ENaC function in a human respiratory epithelial cell model, which can be reversed by adding excess trypsin. At 500 mM, Camostat mesilate inhibits the generation of TGF-β by suppressing plasmin activity and reduces the activity of TGF-beta, thereby blocking the ex vivo activation of hepatic stellate cells (HSC).
Synonyms	FOY-S980, FOY305, Camostat mesilate

Chemical Properties

Molecular Weight	494.52
Formula	C₂₁H₂₆N₄O₈S
Cas No.	59721-29-8
Smiles	CS(O)(=O)=O.CN(C)C(=O)COC(=O)Cc1ccc(OC(=O)c2ccc(NC(N)=N)cc2)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (505.54 mM), Sonication is recommended.

H2O: 49.5 mg/mL (100.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0222 mL	10.1108 mL	20.2216 mL	101.1081 mL
5 mM	0.4044 mL	2.0222 mL	4.0443 mL	20.2216 mL
10 mM	0.2022 mL	1.0111 mL	2.0222 mL	10.1108 mL
20 mM	0.1011 mL	0.5055 mL	1.0111 mL	5.0554 mL
50 mM	0.0404 mL	0.2022 mL	0.4044 mL	2.0222 mL
100 mM	0.0202 mL	0.1011 mL	0.2022 mL	1.0111 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc